Dr. Mandell is a Harvard-trained ophthalmologist and serial entrepreneur with broad drug development experience. Dr. Mandell is founder and CEO of LayerBio, an MIT spinoff developing novel sustained-release implants for ocular applications and previously served as Chief Medical Officer Aramis Biosciences, Intergalactic Therapeutics, Neurotech Pharmaceuticals, and Noveome Biotherapeutics. He is a member of the Board of Directors of Proteris Biotech and the Usher III Initiative and serves an advisor to NexEos Bio and Invirsa, Inc. He has personally contributed to more than a dozen Investigational New Drug (IND) applications and overseen the conduct of numerous Phase 1-3 clinical trials. He has more than 15 granted U.S. patents and is co-inventor of TYRVAYA® (Viatris Inc.) treatment for dry eye disease and Aldeyra’s reproxalap eye drop for ocular inflammation.